{"schemaVersion":"1.0","datasetVersion":"research-20261026-daytab-v1+youth-f164c8325ea5+lab-biofeedback-20261105-ratings","sourceVersions":{"publicationDatabase":"research-20261026-daytab-v1","approvedYouth":{"sourceBatch":"batch-f164c8325ea5f9c9.json","sourceSHA256":"f164c8325ea5f9c989c29524518b598913508117712826dc408f592b7f99a723","approvedAt":"2026-11-02","publications":105},"biofeedback":{"version":"lab-biofeedback-20261105-ratings","publications":63}},"id":"fibonacci-m9-p24","modulus":9,"section":"full","data":{"id":"fibonacci-m9-p24","beta":{"intervals":[{"sum":4,"residue":4,"to_index":4,"from_index":0,"interior_values":[1,1,2],"interior_indices":[1,2,3]},{"sum":17,"residue":8,"to_index":8,"from_index":4,"interior_values":[5,8,4],"interior_indices":[5,6,7]},{"sum":16,"residue":7,"to_index":12,"from_index":8,"interior_values":[7,1,8],"interior_indices":[9,10,11]},{"sum":23,"residue":5,"to_index":16,"from_index":12,"interior_values":[8,8,7],"interior_indices":[13,14,15]},{"sum":10,"residue":1,"to_index":20,"from_index":16,"interior_values":[4,1,5],"interior_indices":[17,18,19]},{"sum":11,"residue":2,"to_index":0,"from_index":20,"interior_values":[2,8,1],"interior_indices":[21,22,23]}],"start_value":4,"cycle_length":6,"display_cycle":[4,8,7,5,1,2],"endpoint_rule":"Exclude endpoints, include wraparound; raw residues used for sums. Empty interiors sum to zero.","interval_sums":[4,17,16,23,10,11],"minimal_cycle":[4,8,7,5,1,2],"native_doubling":true,"circle_positions":9,"interval_residues":[4,8,7,5,1,2],"start_interval_values":[1,1,2],"rotation_to_recognised":4,"m9_doubling_cycle_present":true,"recognised_doubling_cycle":[1,2,4,8,7,5],"start_interval_clock_positions":[24,4]},"name":"Fibonacci M9P24","alpha":{"residues":[0,1,1,2,3,5,8,4,3,7,1,8,0,8,8,7,6,4,1,5,6,2,8,1],"display_values":[9,1,1,2,3,5,8,4,3,7,1,8,9,8,8,7,6,4,1,5,6,2,8,1]},"gamma":{"alpha_indices":[0,4,8,12,16,20],"triangle_paths":[[0,8,16,0],[4,12,20,4]],"clock_positions":[24,4,8,12,16,20],"clockwise_values":[9,3,3,9,6,6]},"views":[{"id":"alpha","png":"pilot-v1/views/m9/alpha.png","svg":"pilot-v1/views/m9/alpha.svg","name":"Alpha"},{"id":"beta","png":"pilot-v1/views/m9/beta.png","svg":"pilot-v1/views/m9/beta.svg","name":"Beta"},{"id":"gamma","png":"pilot-v1/views/m9/gamma.png","svg":"pilot-v1/views/m9/gamma.svg","name":"Gamma"},{"id":"epsilon","png":"pilot-v1/views/m9/epsilon.png","svg":"pilot-v1/views/m9/epsilon.svg","name":"Epsilon"},{"id":"fibonacci-m9p24","png":"pilot-v1/views/m9/fibonacci-m9p24.png","svg":"pilot-v1/views/m9/fibonacci-m9p24.svg","name":"Fibonacci M9P24"}],"family":{"m9":true,"label":"M9 family"},"epsilon":{"status":"Proposed geometric traversal; physical interpretation not assessed.","formation_id":"6-nodes-offset-0","alpha_indices":[0,8,20,12,4,16,0],"clock_positions":[24,8,20,12,4,16,24],"rotation_degrees":0,"traversal_values":[9,3,6,9,3,6,9],"three_step_repeat":true},"modulus":9,"research":{"focus":"OXTR gene expression","tiers":[{"name":"Creates cellular life","range":[8,10],"evidence":[],"wss_score":null},{"name":"Supports cellular life","range":[5,7],"evidence":[],"wss_score":null},{"name":"Creates elemental life","range":[1,4],"evidence":[],"wss_score":null}],"background_literature":{"scope":"Shared background literature for the initial OXTR research programme across M1–M1001. Studies of related mechanisms in other systems provide context for investigation.","register_id":"oxtr-phase1-literature","relationship":"background_context","register_file":"research-register.json","publication_ids":["E01","E02","E03","E04","E05","E06","E07","E08","E09","E10","E11","E12","E13","E14"],"register_version":"2026-10-18.1","hero_publication_ids":["E03","E06","E08","E11"],"modulus_relevance_status":"Not yet assessed"},"quantum_annealing_status":"Not yet performed","biological_significance_status":"Not yet assessed","statistical_significance_status":"Not yet assessed"},"conventions":{"node_rule":"Native residues divisible by 3, including zero; preserves the approved M6/M9/M12 reference selection. Additional regular formations of all native values are catalogued separately.","orientation":"clockwise from north","clock_labels":[24,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23],"index_origin":0,"zero_display":9,"m1_convention":"Modulo 1 has period 1 and residue 0.","beta_circle_positions":9,"alpha_circle_positions":24},"probability":{"id":"m9p24-fixed-gamma-beta-shuffle-v1","files":{"code":"m9-probability.py","data":"m9-probability.json"},"counts":{"all_arrangements":"336614801287564800","matching_arrangements":"1725543","arrangements_given_gamma":"27788080320","qualifying_triple_combinations":198},"method":{"id":"uniform-alpha-shuffle-original-alignment-v1","sampling":"Uniform random permutation of existing 24 Alpha entries, preserving all multiplicities.","beta_rule":"Sum three interior Alpha values in each gap, exclude Gamma endpoints, reduce modulo 9, include wraparound.","beta_values":[4,8,7,5,1,2],"gamma_values":[9,3,3,9,6,6],"gamma_indices":[0,4,8,12,16,20],"comparison_rule":"Preserve each record's original Gamma values, positions and Beta alignment.","alpha_frequencies":{"0":2,"1":5,"2":2,"3":2,"4":2,"5":2,"6":2,"7":2,"8":5},"coordinate_system":"Fixed indices 0..23, clockwise from north; 0 displayed as 9.","beta_interior_indices":[[1,2,3],[5,6,7],[9,10,11],[13,14,15],[17,18,19],[21,22,23]],"gamma_clock_positions":[24,4,8,12,16,20],"allow_rotated_beta_cycle":false,"allow_reversed_beta_cycle":false,"allow_reordered_gamma_values":false,"allow_rotated_gamma_positions":false,"beta_start_interval_clock_positions":[24,4]},"result":{"value":5.1261649618487674e-12,"fraction":"263/51305410956800","numerator":"263","denominator":"51305410956800","one_in_approx":195077608200.76047},"status":"Calculated","display":"Approximately 1 in 195.1 billion","heading":"Probability","summary":"Shuffle the 24 Alpha values around the circle. This is the chance of recovering the original Gamma arrangement and deriving Beta as 4, 8, 7, 5, 1, 2, with the same starting position.","record_id":"fibonacci-m9-p24","calculation":{"steps":["Shuffle the same 24 Alpha values, keeping every value and its frequency.","Place Gamma values 9, 3, 3, 9, 6, 6 at clock positions 24, 4, 8, 12, 16, 20.","Sum the three Alpha values between each pair of Gamma nodes, excluding the endpoints, and reduce each sum modulo 9.","Match Beta to 4, 8, 7, 5, 1, 2, starting with the interval from clock position 24 to 4."],"formula":"1,725,543 / 336,614,801,287,564,800 = 263 / 51,305,410,956,800","counting_note":"For the six Beta intervals, 198 combinations of three-value groups use exactly the available values. Counting the possible orders within each group gives 1,725,543 matching arrangements.","verification_note":"Three exact counting methods agree: remaining-value enumeration, complete three-value-group enumeration, and a separate count treating each card individually."},"verification":{"checks":{"monte_carlo_used":false,"six_rotations_counted_separately":"passed","approved_native_record_assertions":"passed","unrestricted_count_equals_multinomial":"passed","exhaustive_triple_multiset_enumeration":"passed","independent_labelled_bitmask_enumeration":"passed"},"calculation_version":"m9p24-exact-shuffle-v1.1","mathematical_input_sha256":"9ba0cf7032049556812b037a46205b3bb875718b9333f6343d6a5ac5fe487447"},"calculated_on":"2026-10-18","interpretation":{"type":"exact_configuration_shuffle_probability","selection_adjustment_applied":false,"biological_significance_status":"Not yet assessed","statistical_significance_status":"Not yet assessed"},"schema_version":"1.0.0","research_insight":{"quote":"We are exploring equilateral triangles, honeycomb theorem, and carbon structures in relationship to this Atlas for useful directions for computation in OXTR research.","status":"Open research"}},"beta_m9_view":{"version":"beta-m9-view-v1","operation":"Reduce each native Beta residue modulo 9, preserving order and the original start.","native_png":"pilot-v1/views/m9/beta.png","native_svg":"pilot-v1/views/m9/beta.svg","reduced_png":"pilot-v1/views/m9/beta-m9.png","reduced_svg":"pilot-v1/views/m9/beta-m9.svg","drawing_rule":"Plot the six-value cycle once; the repeat count records overlapping traversals. The complete reduced sequence remains available alongside the diagram and in the data.","family_audit":{"summary":"All 111 multiples of nine in M1–M1001 (11.1% of moduli) share this reduced Beta cycle through exact modular reduction.","audit_id":"beta-m9-family-audit-v1","audit_file":"pilot-v1/beta-m9-family-audit.json","modulus_range":[1,1001],"classification":"Exact modular reduction; descriptive coverage","coverage_display":"11.1%","coverage_percent":11.08891108891109,"coverage_fraction":"111/1001","total_moduli_in_range":1001,"family_members_checked":111,"matching_family_members":111},"repeat_count":1,"display_cycle":[4,8,7,5,1,2],"native_values":[4,8,7,5,1,2],"native_modulus":9,"reduced_values":[4,8,7,5,1,2],"target_modulus":9,"reference_cycle_match":true,"native_circle_positions":9,"reduced_circle_positions":9,"original_alignment_preserved":true,"start_interval_clock_positions":[24,4]},"verification":{"scope":"Native period, sequences, regular polygon index spacing and reference Epsilon routes; no physical or biological validation.","python":"Passed","wolfram":"Passed","evidence":"wolfram-core-result.json","wolfram_scope":"24 native periods, complete Alpha, primary Gamma indices, Beta interval sums/residues, primary regular triangles and hexagons. Extended catalogue, Chevron and Epsilon remain Python-checked only."},"pisano_period":24,"epsilon_routes":[{"formation_id":"6-nodes-offset-0","alpha_indices":[0,8,20,12,4,16,0],"clock_positions":[24,8,20,12,4,16,24],"rotation_degrees":0,"traversal_values":[9,3,6,9,3,6,9],"three_step_repeat":true},{"formation_id":"6-nodes-offset-0","alpha_indices":[4,12,0,16,8,20,4],"clock_positions":[4,12,24,16,8,20,4],"rotation_degrees":0,"traversal_values":[3,9,9,6,3,6,3],"three_step_repeat":false},{"formation_id":"6-nodes-offset-0","alpha_indices":[8,16,4,20,12,0,8],"clock_positions":[8,16,4,20,12,24,8],"rotation_degrees":0,"traversal_values":[3,6,3,6,9,9,3],"three_step_repeat":false}],"epsilon_status":"Present","schema_version":"2.2.0","dataset_version":"m1-m48-v1","reduction_to_m9":{"checks":{"beta":true,"alpha":true,"gamma":true,"gamma_indices":true},"status":"Reference","version":"m9-reduction-v1","identity":"(F_n mod (9k)) mod 9 = F_n mod 9","applicable":true,"beta_display":[4,8,7,5,1,2],"repeat_count":1,"verification":"Python full-period comparison; M18 Alpha, Gamma and Beta independently checked with Wolfram.","alpha_display":[9,1,1,2,3,5,8,4,3,7,1,8,9,8,8,7,6,4,1,5,6,2,8,1],"beta_residues":[4,8,7,5,1,2],"gamma_display":[9,3,3,9,6,6],"geometry_note":"M18 and M9 share the same 24-position Gamma geometry. Reduced Beta is plotted on a nine-position circle. Longer periods require folding into 24-position cycles; their full circles are not identical.","alpha_residues":[0,1,1,2,3,5,8,4,3,7,1,8,0,8,8,7,6,4,1,5,6,2,8,1],"gamma_residues":[0,3,3,0,6,6],"interpretation":"Exact reduction is a mathematical consequence of divisibility, not independent evidence of statistical or biological significance. Native Epsilon remains unchanged.","target_modulus":9,"phase_preserved":true,"projected_chevron":true,"research_question":"Does the shared M9 pattern have shared biological relevance, or does native-modulus complexity change it? Unassessed: requires peer-reviewed evidence, in silico modelling (including proposed CUDA/CUDA-Q work), and appropriate experimental validation. No spatial-dimension claim or WSS score follows from this arithmetic match.","native_data_preserved":true,"recognised_beta_cycle":[1,2,4,8,7,5],"biological_significance":"Not yet assessed","projected_beta_circle_positions":9,"gamma_same_single_circle_positions":true},"geometry_summary":{"scope":"Shapes in the primary Gamma node set (native residues divisible by 3, including zero). All regular polygons on the period circle are catalogued separately with their native values; their existence alone is a property of the plotting grid.","shapes":[{"name":"Equilateral triangle","count":2,"status":"Present","alpha_paths":[[0,8,16,0],[4,12,20,4]],"orientation":"North / south","rotation_degrees":null,"rotations_degrees":[0,60]},{"name":"Hexagon","count":1,"status":"Present","alpha_paths":[[0,4,8,12,16,20,0]],"orientation":"North–south","rotation_degrees":0,"rotations_degrees":[0]},{"name":"2D stellated octahedron","count":1,"status":"Present","alpha_paths":[[0,8,16,0],[4,12,20,4]],"orientation":"North–south","rotation_degrees":0,"rotations_degrees":[0]},{"name":"Chevron","count":1,"status":"Present","alpha_paths":[],"orientation":"North–south","rotation_degrees":0,"rotations_degrees":[0]},{"name":"Unicursal hexagram","count":1,"status":"Present","alpha_paths":[[0,8,20,12,4,16,0],[4,12,0,16,8,20,4],[8,16,4,20,12,0,8]],"orientation":"North–south","rotation_degrees":0,"rotations_degrees":[0]}],"circle_role":"Pisano-period plotting framework","epsilon_rule":"A regular six-node formation must support the reference unicursal route through only 3, 6 and 9, containing all three. Rotations and reflections of the route are tested; reversed or cyclically shifted traversals are deduplicated.","rule_version":"native-pilot-v1","other_orientations_status":"Absent"},"m9_sequence_views":{"beta":{"version":"beta-m9-view-v1","operation":"Reduce each native Beta residue modulo 9, preserving order and the original start.","native_png":"pilot-v1/views/m9/beta.png","native_svg":"pilot-v1/views/m9/beta.svg","reduced_png":"pilot-v1/views/m9/beta-m9.png","reduced_svg":"pilot-v1/views/m9/beta-m9.svg","drawing_rule":"Plot the six-value cycle once; the repeat count records overlapping traversals. The complete reduced sequence remains available alongside the diagram and in the data.","family_audit":{"summary":"All 111 multiples of nine in M1–M1001 (11.1% of moduli) share this reduced Beta cycle through exact modular reduction.","audit_id":"beta-m9-family-audit-v1","audit_file":"pilot-v1/beta-m9-family-audit.json","modulus_range":[1,1001],"classification":"Exact modular reduction; descriptive coverage","coverage_display":"11.1%","coverage_percent":11.08891108891109,"coverage_fraction":"111/1001","total_moduli_in_range":1001,"family_members_checked":111,"matching_family_members":111},"repeat_count":1,"display_cycle":[4,8,7,5,1,2],"native_values":[4,8,7,5,1,2],"native_modulus":9,"reduced_values":[4,8,7,5,1,2],"target_modulus":9,"reference_cycle_match":true,"native_circle_positions":9,"reduced_circle_positions":9,"original_alignment_preserved":true,"start_interval_clock_positions":[24,4]},"alpha":{"version":"m9-sequence-view-v1","operation":"Reduce values modulo 9 and fold indices modulo 24, preserving the original start. Repeated 24-position blocks overlap in the diagram.","reduced_png":"pilot-v1/views/m9/alpha-m9.png","reduced_svg":"pilot-v1/views/m9/alpha-m9.svg","family_audit":{"summary":"All 111 multiples of nine in M1–M1001 (11.1% of moduli) recover M9 P24 through exact modular reduction.","audit_id":"m9-sequence-family-audit-v1","audit_file":"pilot-v1/m9-sequence-family-audit.json"},"repeat_count":1,"display_cycle":[9,1,1,2,3,5,8,4,3,7,1,8,9,8,8,7,6,4,1,5,6,2,8,1],"folded_period":24,"native_values":[9,1,1,2,3,5,8,4,3,7,1,8,9,8,8,7,6,4,1,5,6,2,8,1],"native_modulus":9,"reduced_values":[9,1,1,2,3,5,8,4,3,7,1,8,9,8,8,7,6,4,1,5,6,2,8,1],"target_modulus":9,"reference_cycle_match":true,"native_circle_positions":24,"reduced_circle_positions":24,"original_alignment_preserved":true},"gamma":{"version":"m9-sequence-view-v1","operation":"Reduce values modulo 9 and fold indices modulo 24, preserving the original start. Repeated 24-position blocks overlap in the diagram.","reduced_png":"pilot-v1/views/m9/gamma-m9.png","reduced_svg":"pilot-v1/views/m9/gamma-m9.svg","family_audit":{"summary":"All 111 multiples of nine in M1–M1001 (11.1% of moduli) recover M9 P24 through exact modular reduction.","audit_id":"m9-sequence-family-audit-v1","audit_file":"pilot-v1/m9-sequence-family-audit.json"},"repeat_count":1,"display_cycle":[9,3,3,9,6,6],"folded_period":24,"native_values":[9,3,3,9,6,6],"native_modulus":9,"reduced_values":[9,3,3,9,6,6],"target_modulus":9,"reference_cycle_match":true,"native_circle_positions":24,"reduced_circle_positions":24,"original_alignment_preserved":true},"epsilon":{"version":"m9-sequence-view-v1","operation":"Reduce Alpha modulo 9, then apply the fixed M9 Epsilon route within each 24-position block: 0 → 8 → 20 → 12 → 4 → 16 → 0. This is a cycle-based construction; native full-circle Epsilon is assessed separately.","reduced_png":"pilot-v1/views/m9/epsilon-m9.png","reduced_svg":"pilot-v1/views/m9/epsilon-m9.svg","family_audit":{"summary":"All 111 multiples of nine in M1–M1001 (11.1% of moduli) recover M9 P24 through exact modular reduction.","audit_id":"m9-sequence-family-audit-v1","audit_file":"pilot-v1/m9-sequence-family-audit.json"},"repeat_count":1,"display_cycle":[9,3,6,9,3,6,9],"folded_period":24,"native_modulus":9,"reduced_values":[9,3,6,9,3,6,9],"target_modulus":9,"block_traversals":[{"block":1,"alpha_indices":[0,8,20,12,4,16,0],"native_values":[9,3,6,9,3,6,9],"reduced_values":[9,3,6,9,3,6,9]}],"native_369_qualifies":true,"reference_cycle_match":true,"native_circle_positions":24,"reference_alpha_indices":[0,8,20,12,4,16,0],"reduced_circle_positions":24,"original_alignment_preserved":true,"native_full_circle_comparison":{"scope":"Tests the fixed north-oriented M9 path on the full native period circle; does not fold the period or rotate/reverse the values to force a match.","reason":"Exact geometry and reduced traversal match.","orientation":"clockwise from north; fixed M9 route and starting phase","rule_version":"epsilon-m9-exact-v2","alpha_indices":[0,8,20,12,4,16,0],"native_values":[9,3,6,9,3,6,9],"clock_positions":[24,8,20,12,4,16,24],"reference_values":[9,3,6,9,3,6,9],"combined_eligible":true,"reduced_m9_values":[9,3,6,9,3,6,9],"geometry_identical":true,"normalized_route_sixths":[0,2,5,3,1,4,0],"reduced_sequence_identical":true}}},"research_register":{"id":"oxtr-phase1-literature","wss":{"score":null,"status":"Awaiting assessment","meaning":"Future assessment of relevance to individual Atlas records. Publication trust scores remain separate from WSS."},"scope":"Shared background literature for the initial OXTR research programme across M1–M1001. Studies of related mechanisms in other systems provide context for investigation.","title":"First Principles Genomics — research register","version":"2026-10-18.1","hypothesis":"The Alpha, Beta, Gamma and Epsilon sequences of M9P24 may offer useful descriptions of biological timing, cellular division and molecular organisation in the context of OXTR. Bioinformatics and in silico modelling provide the planned means of investigation.","publications":[{"id":"E01","doi":"10.1126/science.1108451","hero":null,"year":"2005","jadad":"Not applicable","limit":"biochemical reconstruction is more informative about mechanism than visual analogy. It is a cyanobacterial system, not a mammalian receptor study, and does not support a universal exact 24-hour period or M9 correspondence.","score":6,"theme":"Alpha · circadian timing","title":"Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro","access":"primary abstract and publication metadata. Replication and detailed methods require full-text appraisal before a formal quality rating.","author":"Nakajima et al.","finding":"KaiA, KaiB, KaiC and ATP supported self-sustaining phosphorylation oscillation. Temperature compensation and agreement between mutant periods in vitro and in vivo strengthened the biological interpretation.","journal":"Science","methods":"Purified cyanobacterial clock proteins; biochemical reconstitution","relevance":"direct evidence for a molecular timing mechanism; a broad Alpha reference independent of OXTR.","scoreParts":{"design":3,"review":1,"provenance":1,"validation":1},"scoreReason":"Molecular reconstitution tests a timing mechanism; appraisal currently covers the abstract and metadata.","citationCount":1020,"crossrefTitle":"Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro","citationSource":"Crossref cited-by count","citationChecked":"17 October 2026"},{"id":"E02","doi":"10.1073/pnas.1320474111","hero":null,"year":"2014","jadad":"Not applicable","limit":"single-cell observations support the dynamical interpretation. Culture conditions and synchronisation matter, and related cells are not automatically independent replicates. No modular doubling or Atlas geometry was tested.","score":7,"theme":"Alpha / Beta · cycle coupling","title":"Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle","access":"primary abstract and selected results, including period distributions. A phase-space representation is not evidence of a physical toroidal cell structure.","author":"Feillet et al.","finding":"live imaging of proliferating mouse fibroblasts, combined with modelling, identified phase locking and additional clock states under different conditions.","journal":"PNAS","methods":"Mouse fibroblasts; live-cell imaging and modelling","relevance":"direct support for studying relationships between biological cycles; connects the Alpha and Beta research themes without making them equivalent.","scoreParts":{"design":2,"review":2,"provenance":1,"validation":2},"scoreReason":"Live-cell observations and modelling provide complementary evidence for phase locking; selected results appraised.","citationCount":216,"crossrefTitle":"Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle","citationSource":"Crossref cited-by count","citationChecked":"17 October 2026"},{"id":"E03","doi":"10.1016/j.molmet.2025.102269","hero":"alpha","year":"2026 (online 2025)","jadad":"Not applicable","limit":"genetic perturbation and promoter experiments strengthen mechanism. Animal, cell and retrospective components need separate appraisal; the human observations can be confounded. Uterine findings do not establish effects in brain tissue.","score":8,"theme":"Alpha · circadian regulation","title":"Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes","access":"final publication abstract and selected full-text results. The 2024 preprint is superseded for this register and is not counted as another study.","author":"Duong et al.","finding":"mouse experiments support BMAL1 regulation of Oxtr and time-dependent oxytocin responsiveness. Human myometrial-cell experiments and records from 2,367 patients add distinct translational observations.","journal":"Molecular Metabolism","methods":"Mouse genetics; human cells; retrospective human records","relevance":"a direct OXTR connection to the Alpha theme.","scoreParts":{"design":3,"review":2,"provenance":1,"validation":2},"scoreReason":"Genetic and promoter experiments support mechanism; the human observational component has separate confounding limits.","citationCount":3,"crossrefTitle":"Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes","citationSource":"Crossref cited-by count","citationChecked":"17 October 2026"},{"id":"E04","doi":"10.1038/nature10700","hero":null,"year":"2011","jadad":"Not applicable","limit":"molecular interactions, genetic perturbations and physiological observations complement one another. Multiple pathways change in knockout animals; the results do not isolate a universal geometric explanation or establish human clinical effects.","score":8,"theme":"Alpha · receptor regulation","title":"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor","access":"primary abstract and selected experimental/results text. NR3C1 identifies the receptor target; the principal genetic perturbations here involved cryptochromes.","author":"Lamia et al.","finding":"Cry1/Cry2 interacted with the glucocorticoid receptor and altered glucocorticoid-responsive transcription in mouse cells, with related metabolic phenotypes in mice.","journal":"Nature","methods":"Mouse cells and mice; genetic and biochemical experiments","relevance":"direct circadian–receptor evidence provides a natural NR3C1 example beyond oxytocin.","scoreParts":{"design":3,"review":2,"provenance":1,"validation":2},"scoreReason":"Genetic perturbations, molecular interactions and physiological measurements support the reported mechanism.","citationCount":550,"crossrefTitle":"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor","citationSource":"Crossref cited-by count","citationChecked":"17 October 2026"},{"id":"E05","doi":"10.1038/nature05786","hero":null,"year":"2007","jadad":"Not applicable","limit":"manipulation of the cell environment offers more than an observational resemblance. The model uses specific force assumptions and a transformed cell line. Division orientation is distinct from division rate, population doubling or a Fibonacci sequence.","score":6,"theme":"Beta · mitotic geometry","title":"Experimental and theoretical study of mitotic spindle orientation","access":"publisher abstract and figure descriptions. 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Check independent cell lines and differentiation batches; images are subsamples, not donors. Cultured epicardial cells and fish regeneration do not establish regeneration of adult human hearts.","score":9,"theme":"Beta · proliferation","title":"Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury","access":"primary full-text methods/results and relevant figure captions, including OXTR knockdown and proliferation measurements.","author":"Wasserman et al.","finding":"OXT promoted activation and proliferation-related outcomes in human stem-cell-derived epicardial cells; OXTR knockdown removed the response. 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